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+# Lymphocytes
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+## Introduction
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+- T-Lymphocytes (Thymus): cellular
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+- B Lymphocytes (Bone Marrow): humoral
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+- NK (Natural Killer)
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+- Most undergo further antigen-mediated differention in lymphoid organs, but not a small subset of CD4+T
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+- CD4+T and CD8+T majorty of T-Lymphocytes
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+
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+## CD4T+
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+- Effector subtypes
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+- Activate Innate Immune, B, Cyto-T, and other cells
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+- Suppress immune reaction
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+- Subtypes: Th1, Th2, Th-17, Tfh, iTreg, Tr1, Th9
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+
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+## Lymphopoiesis
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+- Thymocytes from hematopoietic stem cell (marrow) come to thymus
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+- Thymus: primary lymphoid organ provides microenvironment of stromal cells, cytokines and chemokines to generate T-cells from thymocytes
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+- Gene rearrangement and thymocyte selection
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+- Affinity model (to peptide complex on Antigen-presenting cells APC):
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+ - low affinity thymocytes die
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+ - high affinity are destroyed
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+ - intermediate affinity are differentiated into CD4/8+
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+- CD4+: nTreg, NKT (also CD4-CD8-), mature-naive
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+- CD8+: MHC1b, MR1 mucosa-associated
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+
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+## Activation and Differentiation
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+-
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