# Intro - Compusci/EE AI conversational interfaces -> Siri/Echo - Environmental chemicals and disease # Concerns - Synthetic cationic lipids (toxicity) - Easily taken up by cells (LDL-like) - mRNA remains intact and resistant against enzymes - RNA redesigned to look more like human molecule - Uridine replaced with pseudouridine - 2 prolines added to middle of sequence - Locked spike disables ACE-2 Receptors - Codon optimized for maximum protein production - UTRs attached to ends of sequence - Spike and mRNA both remain in lymph nodes > 60 days - Tremendous antibody response - Narrow focus on spike - mRNA and spike in bone marrow # Reproductive - Mice study injected IgG Ab into peritoneum of pregnant mice - Baby mice had severe brain inflammation # Cancer - Spike suppressing BRCA protein (associated with breast cancer) - VAER strong breast cancer signal -