# Introduction
Basic immunology is being neglected. This is not political. Simply from the perspective of a scientist and a physician, the proposal to use mRNA vaccines as a means of immunizing oneself against a respiratory disease is flawed from the perspective of first principles.

mRNA vaccines are planned for use in the replacement of all traditional vaccines, as well as new treatments such as those for oncology. Strange that there is a lack of awareness concerning basics that can be found in first year immunology/microbiology textbooks.

## Protein Fragments
When a cell makes a protein, fragments of the protein always are presented at the surface of the cell. Like sawdust when sawing wood - waste products/fragments that will be recognized by your lymphocytes, which have receptors which will fit the fragments being presented. These lymphocytes all carry different receptors bearing different degrees of differentiation, in order to meet any of the requirements that might be presented.

## Lymphocyte receptor enigma
What comes first? Do the fragments first influence the receptor types that are carried by these lymphocytes? Or are the lymphocytes already equipped with the receptors to bind to all the prospective biological sequences they might come into contact with?

This enigma was solved decades ago and resulted in a Nobel Prize.
- In the womb, we generate a diversity of receptors so that we have millions of lymphocyte clones with each a different receptor type.
- Some receptors are for proteins deriving from self
  - These are kept in check or are silenced, throughout life
- We also carry receptors on T-cell clones that can recognize non-self
- With every round of "training", our T-cells better, stronger and faster
- Children repeately have viral infections, but deal with them more rigorously/successfully
- Virus infections, on the whole, are not mortally dangerous

## B-cells
- T-cells activate B-cells which make antibodies to the proteins, such as a spike protein.
- If antibodies could reach out and grab the virus as it comes into the body, it could prevent antigenic protein from binding to normal cells
- In the case of SARS-CoV2, the mRNA vaccines don't produce antibodies that can affect the respiratory tract
- Virus being "less susceptible" to capture is nonsense, because it would never be captured except in advanced disease where the blood system is overrun

## Real Protection
- T-cells are the basis of all protection against viruses
- Antibodies play a subordinate role
- Everyone has T-cells directed against Coronaviruses, because they're so prevalent.
- Mutations only affect 1 or 2 protein fragments at a time
- Recognizable structures always remain, thus there's no necessity to have a vaccine

## Intramuscular
- Vaccines were supposed to stay in the muscle
- Expression was supposed to occur at the muscle
- mRNA vectors can't be recognized by the immune system
- Lymph nodes or nerves until eventually meeting the bloodstream
- Cannot stop them from getting into the bloodstream
- What happens, now, is that these packaged genes travel in the blood stream and your blood vessels are a closed system of pipes going throughout all the organs of your body and the cells lining your vessel wall, the endothelial cells, are the most abundant nucleated cells in your body. You have blood vessels going throughout the body. The blood and their components stay in those vessels, unless you have damage to the vessels.
- Packaged genes remain trapped in the blood vessels thus they are taken up by the cells that line the vessel walls.