# ADE Concerns
One of the issues with the ADE is that it's not so clear and cut that we're able to detect it. There are always going to be a massive number of confounding variables, so detecting whether or not someone's susceptibility to a disease has been altered by an intervention is always going to be tricky. Unless the pathology is so incredibly enhanced that a harmless disease becomes a deadly one in a majority of persons, it's quite possible that a moderate to significant change of pathology could be induced without anyone realizing the change.

Immunopathology
- There is no clear control group. We're essentially going on diagnoses, observations and subsequent analyses performed for on in-patients, with a possible autopsy being performed on some. If the majority of persons have received the vaccine, however, then the comparative severity is going to become even more difficult to compare.

Adaptation to virus
- The virus has been part of the environment for some time now
- Mutation of virus is expected to reduce virulence while increasing transmissibility

Observability
- There's no reliable way of differentiating between antibodies which contribute to ADE vs ones which effectively neutralize a pathogen
- There's