Richard Fleming Notes

Antibiotic Bacterial Resistance

Strains which survive antibiotic use are resistant
We are doing similarly with vaccination

The Spike

Code being produced is for SARS-CoV Wuhan HU1
Nucleotide sequences don't perfectly match HU1

Immune Layers

Innate
Macrophage eats virus and presents
Naive T cells react to become T-helper 1 and T-helper 2
TH-1 cytotoxic which kill infected cell
TH-2 effector which induces creation/updating of B cell

Skipping Step

The mRNA vaccines don't seem to induce differentiation of T-helper 2 cells.

Possibly because the virus is not seen outside of cells.
Nanolipid particle technique bypasses this
Blunted interferon response

EUA Documents

Don't show the cell differentiation statistics
Only show recording of symptoms / illness

Diminishing natural immunity

Taking the mRNA shots causes reduced response to other non-CoV pathogens

Biodistribution

Moderna 2017 did nanolipid influenza study and discovered that it spread to brain and bone marrow etc.
Lipid nanoparticles great way to get into cells - merge with cell wall

Immune research

Research on immunity has always favoured Ab response. T cell assays are complicated, require more training, more expensive reagents/equipment, etc.
hampered immune response might mean require higher Ab counts

Spike load

Person to person transmission means exposure to 100s - 10000 spikes
Pfizer/Moderna 13.1 billion codes?
AZ/Jannsen 50 billion