This is based on a new medRxiv pre-print study entitled: "The BNT162b2 mRNA vaccine against SARS-CoV-2 reprograms both adaptive and innate immune responses".
Many immunologists, vaccinologists, biostatisticians and others have made a variety of assertions about the mRNA-based SARS-CoV-2 injections, and though there have been many disagreements about the credulity and accuracy, there are good reasons for better understanding what might possibly be occurring.
For example, it's known that the T-2 effector response is unlike what would be encountered with a natural infection. There's the pattern of distribution as per the pharmacokinetics of vector delivery, the factor of the synthetic cationic lipids functioning as adjuvants, the fact of their lipophilic properties, and so forth.
The paper is important as it expands and elucidates the discussion surrounding immune system dysregulation, and how this is not only with respect to the adaptive immune system, but even the innate system, whose maintained functionality is an important aspect to be considered in avoiding the pitfalls of aging and senescence.
Some of these observations are also relevant in understanding the vaccine adverse reports, which are mostly discounted and functioning as a means to place data that we aren't too eager to analyze.
Understanding how the mRNA products affect innate immunity is paramount, as one of the strongest differentiating factors in predicting disease outcomes is on the basis of one's innate immunity. That is to say, children do much better than adults particularly because they have such strong innate immune systems. This is also quite important when considering future infections with as-of-yet undiscovered pathogens for which no vaccine exists. That is to say, though we might benefit from cross-reactive immunity on the basis of adaptive responses we've made to pathogens who share genetic similarity with a prospective pathogen, we need to always be aware of the lowest common denominator which will affect all circumstances, including the ones for which no adaptive immunity exists, and this is particularly why we would do well to always prioritize innate immune health for as long as we can maintain it.
These types of responses target invading cells and cancer cells quite generally.
Mucus layer covering the epithelium is the first physical and biochemical defense layer. A tightly interlaced network of epithelial cells and intraepithelial lymphocytes are also somewhat the first line of defense.
Anti-microbial peptides are produced by the epithelial cells and secreted into lumen upon infection by foreign pathogens.
Pathogen-Associated Molecular Patterns (PAMP):
PAMP is detected by PRR (like TLR), and causes a signalling cascade which eventually produces inflammatory mediators (NO, histamine, TNF-a, IL-1)
Childrens' innate immunity performs too well for an infection to become out of control.