logicp_writings/covidism/Jessica_Rose-Reprogramming_immunity.md

Pfizer Reprograms Adaptive and Innate Immunity

This is based on a new medRxiv pre-print study entitled: "The BNT162b2 mRNA vaccine against SARS-CoV-2 reprograms both adaptive and innate immune responses".

Many immunologists, vaccinologists, biostatisticians and others have made a variety of assertions about the mRNA-based SARS-CoV-2 injections, and though there have been many disagreements about the credulity and accuracy, there are good reasons for better understanding what might possibly be occurring.

For example, it's known that the T-2 effector response is unlike what would be encountered with a natural infection. There's the pattern of distribution as per the pharmacokinetics of vector delivery, the factor of the synthetic cationic lipids functioning as adjuvants, the fact of their lipophilic properties, and so forth.

The paper is important as it expands and elucidates the discussion surrounding immune system dysregulation, and how this is not only with respect to the adaptive immune system, but even the innate system, whose maintained functionality is an important aspect to be considered in avoiding the pitfalls of aging and senescence.

Some of these observations are also relevant in understanding the vaccine adverse reports, which are mostly discounted and functioning as a means to place data that we aren't too eager to analyze.

Understanding how the mRNA products affect innate immunity is paramount, as one of the strongest differentiating factors in predicting disease outcomes is on the basis of one's innate immunity. That is to say, children do much better than adults particularly because they have such strong innate immune systems. This is also quite important when considering future infections with as-of-yet undiscovered pathogens for which no vaccine exists. That is to say, though we might benefit from cross-reactive immunity on the basis of adaptive responses we've made to pathogens who share genetic similarity with a prospective pathogen, we need to always be aware of the lowest common denominator which will affect all circumstances, including the ones for which no adaptive immunity exists, and this is particularly why we would do well to always prioritize innate immune health for as long as we can maintain it.

Background

Natural Killer (NK) Cells

• These cells kill infected cells
• exist of at the intersection of innate and adaptive immune system

Emitted signals

• Molecules are emitted when immune cells encounter foreign bodies
• Defensins (small cysteine-rich cationic proteins)
  • antibiotic activity
  • regulate inflammation, wound repair, immune signaling
• Collectins (collagen-containing C-type lectins)
  • Help to induce complement activation
  • Prompt phagocytes to consume foreign cells
• C-reactive proteins
• Lipopolysaccharide-binding proteins
• Other complement factors

These types of responses target invading cells and cancer cells quite generally.

Modifications

• The BNT162b2 products modulate production of inflammatory cytokines by innate cells
• This modified production is observed both with:
  • SARS-CoV-2 (the pathogen for which it was designed)
  • Non-specific stimuli (viral, fungal, bacterial)
• Fungal cytokine responses are increased
• Toll-receptor responses (TLR4 an TLR7/8) are weaker

Innate Immunity

• First response
• Skin (epidermal dendritic cells / Langerhans cells)
• Mucous
• Mucosal epithelium
• Immune cells (NK, Basophils, dendritic, mast, macrophages, etc)

Mucus layer covering the epithelium is the first physical and biochemical defense layer. A tightly interlaced network of epithelial cells and intraepithelial lymphocytes are also somewhat the first line of defense.

Anti-microbial peptides are produced by the epithelial cells and secreted into lumen upon infection by foreign pathogens.

Pattern Recognition

Pathogen-Associated Molecular Patterns (PAMP):

• detected by cognate molecules on immune cell surfaces
• Pattern recognition receptors help to make this a reality
  • Toll-Like Receptors (TLR)
  • Many types which bind to different molecules
  • TLR-7 binds to RNA (single-stranded) -> like SARS-CoV-2!
  • RIG-I-Like receptors (RLR) does similar sensing of viral RNA

PAMP is detected by PRR (like TLR), and causes a signalling cascade which eventually produces inflammatory mediators (NO, histamine, TNF-a, IL-1)

Nuclear Factor kappa B (NF-kB)

• Regulates immune response to infection
• Disregulated NF-kB responses have been associated with disease:
  • cancer, autoimmune conditions, impaired immune development

Event Sequence of SARS-CoV-2 infection

1. Viral particles are sneezed over someone's face
2. Enters nassal cavity as a misty droplet
3. Encounters mucousy membranes - get stycj
4. Bind to ACE-2 and CD147
5. Replicate in epithelial cell
6. Visited by dendritic cells and marked for destruction

Childrens' innate immunity performs too well for an infection to become out of control.

Event Sequence of mRNA Injection

1. Inserted deep in muscle tissue
2. Easy access to most cells
3. Translated through ribosomes into proteins
4. Spike protein attracts antigen-presenting cells
5. Presented to T cells w